Original article

Korean Journal of Schizophrenia Research 2009;12(2):83-89.

만성 정신분열병 입원 환자에서 대사증후군의 유병률

Joo-Tae Jeong, MD, Bo-Hyun Yoon, MD, PhD, Tae-Un Kim, MD, Young-Hwa Sea, MD, Soo-Hee Park, MD, Kang-Young Jeong, MD and Ahn Bae, MD, PhD

Abstract

Objective: The prevalence of metabolic syndrome in schizophrenic patients is known to be 2-3 times increased than general population. But there is little data on the metabolic syndrome in Korean schizophrenic patients. Therefore, the purpose of this study was to evaluate the prevalence of metabolic syndrome in Korean schizophrenic inpatients.
Methods:Schizophrenic inpatients who met the diagnosis of DSM-IV were included. Body weight, height, waist circumference and blood pressure were directly checked by the authors. Data on blood glucose, triglyceride, HDL-cholesterol were gathered from the fasting state blood samples before breakfast. Metabolic syndrome was defined by revised National Cholesterol Education Program- Adult Treatment Panel III (revised NCEP-ATP-III) and criteria of International Diabetes Federation (IDF).
Results:A total of 214 inpatients were included. Forty-four (20.6%) and 40 (18.7%) of them were diagnosed as metabolic syndrome by criteria of revised NCEP-ATP III and IDF, respectively. Of the 5 cardiometabolic risks, only abdominal obesity was more common in women. The frequencies of the cardiometabolic risks were as follows；low HDL-cholesterol (68%), abdominal obesity (43%), triglyceridemia (29.4%), hypertension (12.1%) and impaired blood glucose level (9.3%). The most common combination of cardiometabolic risks in metabolic syndrome was abdominal obesity+triglyceridemia+low HDL-cholesterol (45.5%). The correlations of metabolic syndrome with age, sex, age at onset, duration of illnesses, and number of antipsychotics were not significant.
Conclusion:Our results suggest that the prevalence of metabolic syndrome in schizophrenic inpatients may be twice than that of general population in Korea. Of the cardiometabolic risks, low HDL-cholesterol and abdominal obesity were common and significant in schizophrenic inpatients. (Korean J Schizophr Res 2009;12:83-89)

Key Words: Metabolic syndrome,Schizophrenic,Inpatients,NCEP-ATP,IDF.