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Korean Journal of Schizophrenia Research 2010;13(2):67-73.
정신분열병과 분열정동장애 환자에서 고용량 Quetiapine(>800 mg/day) 사용의 효과와 안전성
Ok-Jin Jang, MD1, Yang-Tae Kim, MD1, Jeong-Gee Kim, MD, PhD2 and Chan-Woo Kim, MD2
Abstract
Objectives:The aim of this study was to investigate the efficacy and safety of high dose quetiapine treatment (>800 mg/day) in patients with schizophrenia or schizoaffective disorder.
Methods:This was retrospective, naturalistic study using the data from medical record. The subjects were inpatients diagnosed with schizophrenia or schizoaffective disorder according to criteria of DSM-IV TR and treated with high dose quetiapine. To assess the safety, we divided the period into 3 stages by daily dosage as ≤500 mg, 500-800 mg and >800 mg and surveyed the side effects for each stage. Efficacy was assessed by PANSS scores on a weekly basis. Finally we examined the differences between only-quetiapine use group and non only-quetiapine use group which either switched or added to other antipsychotics.
Results:The most common side effects of high dose quetiapine were drowsiness, dry mouth and dizziness. Compared with recommended dosage (300-800 mg/day), the side effects such as EPS, dysarthria, blurred vision and voiding difficulty increased, but there was no statistic significance. The PANSS scores gradually decreased as dose increased. Meanwhile, those who showed better therapeutic responses in recommended dosage, lower scores in initial total PANSS, younger at first admission, and older in the onset had better therapeutic responses in high dose quetiapine and more likely to stick to quetiapine treatment.
Conclusion:The use of high dose quetiapine had tolerable side effects on schizophrenia and schizoaffective disorder. And those who showed better therapeutic responses in recommended dosage, younger at first admission and older in the onset had better therapeutic efficacy. (Korean J Schizophr Res 2010;13:67-73)
Key Words: High dose quetiapine,Safety,Efficacy.
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