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Korean J Schizophr Res > Volume 15(2); 2012 > Article
Korean Journal of Schizophrenia Research 2012;15(2):90-98.
DOI: https://doi.org/10.16946/kjsr.2012.15.2.90    Published online October 31, 2012.
Pilot Study on Resting-State Functional Connectivity under the Effects of Familial Loading in People at Ultra-High Risk for Psychosis.
Beom Jun Min, Tae Young Lee, Sung Nyun Kim, Hyun Jung Han, Da Jung Shin, Seo Hyun Jo, Jun Soo Kwon
1Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. kwonjs@snu.ac.kr
2Department of Brain and Cognitive Sciences, WCU, Seoul National University, Seoul, Korea.
3Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, Korea.
Abstract
OBJECTIVES
People at ultra-high risk for psychosis have heterogenous character and different long-term outcomes. We divided ultra-high risk subjects into two subgroups by presence of familial history and tried to find different pattern of functional connectivity of the default mode network (DMN) between the two groups in order to examine the effects familial loading.
METHODS
Eleven subjects at clinical-high risk (CHR) group with familial history of psychiatric illness and nineteen subjects of CHR group without familial history were recruited. All the subjects were scanned using resting-state functional magnetic resonance imaging. A posterior cingulate cortex was the seed region of the analysis, and the DMN of the both high risk group were analyzed with voxel-wise two sample T test.
RESULTS
The CHR group with familial history showed greater functional connectivity in the precuneus area in contrast with the other high risk subjects (peak-level t=5.49, p<0.001). There were no significant differences in total score on the Positive and Negative Syndrome Scale and Scales of Psychosis-risk Syndrome between the two groups.
CONCLUSION
The study suggests that the abnormalities of functional connectivity between precuneus and posterior cingulate area may be associated with the genetic vulnerability of high risk trait.
Key Words: Ultra-high risk for psychosis · Familial loading · Default mode network · Precuneus
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